Abstract
Genetic variation is considered to strongly impact on detoxification of carcinogens and therefore is related to cancer risk. However, findings for the null genotypes of GSTT1 and GSTM1 have not always been consistent. Therefore the present meta-analysis was conducted. We accessed the reported study at different research areas and used various databases, including PubMed and Wanfang Med Onlion from 1990 to May 1st 2013. We calculated the odds ratio (OR), 95% confidence interval (CI) and P value for oral cancer by using Review Manager 5.1 and STATE 12. We found that there was no increased oral cancer risk among subjects carrying GSTM1 and GSTT1 null genotype (OR=1.35, 95%CI=0.68-2.68, P=0.39) and (OR=1.41, 95%CI=0.72-2.77, P=0.31) in the Chinese population. In contrast, in studies in India a significant correlation between GSTM1 null genotype and oral cancer was observed (OR=1.59, 95%CI=1.20-2.11, P=0.001), but not in GSTT1 (OR=1.21, 95% CI = 0.84-1.74, P=0.31). We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.
Highlights
Oral cancer is one of the most common cancers in the world (Petersen, 2009)
We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population
Characteristics of studies According to the search strategy, 15 papers were selected in this meta-analysis in Figure 1. 10 studies included 1630 cases and 2728 controls were about GSTM1 and oral cancer in India population. 10 studies included 1562 cases and 2526 controls were about GSTM1 and oral cancer in India population. 5 studies included 919 cases and 1097 controls were about GSTM1 and oral cancer in Chinese population. 5 studies included 619 cases and 797 controls were about GSTT1 and oral cancer in Chinese population
Summary
Oral cancer is one of the most common cancers in the world (Petersen, 2009). The incidence of oral cancer has increased obviously in the last few years in different Asian populations (Sato et al, 1999; Masood et al, 2013). Some studies had demonstrated that smoking and alcohol consumption were two risk factors of oral cancer (Katoh et al, 1999; Xie et al, 2004; Sugimura et al, 2006;Cha et al, 2007; Halawany et al, 2013; Menezes et al, 2013). Other studies were focus on genetic polymorphisms. Previous studies demonstrated that null genotype of GSTM1 and GSTT1 was correlated to the susceptibility to oral cancer (Seidegard et al, 1988; Hayes and Pulford, 1995; Gronau et al, 2003; Ma et al, 2011).
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