Abstract
Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case-control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg’s test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta-analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37–1.85). By contrast, the results revealed a significant association for the comparison of null vs. non-null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09–2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well-designed methodologies are required to verify these conclusions.
Highlights
Osteosarcoma is a highly malignant and aggressive bone tumor, occurring primarily in individuals between 10 and 30 years old [1]
As important phase II enzymes, the GSTM1 and GSTT1 null genotypes are known to eliminate enzyme activities; these null genotypes have been linked with the increased number of cancer cases, possibly due to increased susceptibilities to environmental toxins and carcinogens [13]
The association between GSTM1 and GSTT1 null genotypes and osteosarcoma risk has been investigated in several studies [15,17,18]; the results of these studies are controversial
Summary
Osteosarcoma is a highly malignant and aggressive bone tumor, occurring primarily in individuals between 10 and 30 years old [1]. Molecular biology studies have revealed strong evidence that genetic factors are important in the pathogenesis of osteosarcoma [4,5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
