Nucleotide sequence of the cynomolgus monkey apolipoprotein A-I gene and corresponding flanking regions

Abstract

The cynomolgus monkey ( Macaca fascicularis) apolipoprotein A–I (apo A–I) gene and corresponding flanking regions have been isolated from a cynomolgus monkey genomic library and completely sequenced. Comparison with the human sequence shows a > 90% homology with the monkey sequence, overall. The monkey apo A–I structural gene (1856 bp) is representative of the general apolipoprotein gene structure and consists of four exons and three introns. Minor differences exist between the monkey and human structural gene sequence but do not result in significant changes. Sequences preceding the putative monkey apo A–I promoter are virtually identical to the human apo A–I enhancer region with an exact match to the three enhancer DNA binding sites.