Abstract
The oncogenic retroviruses can be divided into three classes. One class, exemplified by avian Rous sarcoma virus (RSV), is replication-competent and carries a transforming gene, in this case the src gene. The second class carries a transforming gene, but is replication-defective and therefore requires a helper virus for growth. Examples of these viruses are Abelson, Moloney sarcoma, and spleen focus-forming viruses. The third, and to us most intriguing, class consists of those viruses that are replication-competent, but do not carry extra transforming genes. Mouse leukemia viruses, those designated mink-cell focus-inducing (MCF) and discussed in detail by Rowe et al. (this volume), are of this sort.
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