Abstract
We present the nucleotide sequence of a cDNA coding for cyclophilin homologue of the sea urchin Hemicentrotus pulcherrimus. The 1,755-nucleotide sequence contains a 492-bp open reading frame corresponding to a translation product of 164 amino acids. Comparison of the deduced amino acid sequence with the previous data shows a high degree of conservation (approximately 80% homology). Southern blot analysis of genomic DNA suggests the presence of a multigene for sea urchin cyclophilin. Northern blot analysis indicates a mRNA size of approximately 3 kb and that message is accumulated at blastula stage.
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