Abstract
Nucleosome sliding and nucleosome digestion are two main ways for regulating gene transcription. We constructed three characteristic parameters (CP) based on the information of CG0, CG1 and CG2 motifs, and used these parameters to analyze the sliding trend of -1 and +1 nucleosomes around TSS of genes with NFR in yeast. The CP distribution was used to describe the features of nucleosome sequences, and the slope of fit line of CP distribution curve was used to represent the potential energy of nucleosome sequences. Results show that nucleosome sliding trend could be reflected by CG0 and CG2 CP distributions, and CG0 CP distribution has a good correlation with nucleosome sliding trend. In addition, the sliding trend of nucleosomes is different in various expression level genes. For high expression gene, sliding trend of -1 nucleosome is weaker and that of +1 nucleosome is stronger.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
