Abstract
The reactions of poly(β-chloroethyl-glutamate) (PCIEG) or poly(j -cyanoethyl-glutamate) (PCNEG), obtained from poly(methyl-glutamate) (PMG) by transesterfication, with some nudeophilic reagents such as sodium azide sodium dithiocarbamate and amines were investigated. When PC1EG was treated with sodium azide at 600G and 850C or with sodium N, N-dimethyldithiocarbamate at 400C in N, N-dimethylformamide, j9-chlorine of PC1EG was substituted selectiveLy and effectively by azide or dithiocarbamate groups, respectively. The aminolysis of PMG was found to take place very slowly at these temperature and to occur predominantly on main chains at higher temperatures. In contrast, the aminolysis of PC1EG and PCNEG proceeded easily on pendant ester moieties even at 10.By using the above procedures, versatile derivatives of poly(glutamates) containing hydrazide, hydroxamic acid, I -hydroxy-ethyl-amide, and -aminoethyl-amide groups were prepared.
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