Abstract
Synthetic and biological interest in highly functionalized acyclic and cyclic amines has contributed to the wealth of experimental methodology developed for the addition of carbanions to the carbon–nitrogen double bond of imines/imine derivatives (azomethines). While a variety of practical methods exist for the enantio- and stereo-selective syntheses of substituted alcohols from aldehyde and ketone precursors, related imine additions have inherent structural limitations. Nonetheless imines, by virtue of nitrogen substitution, add a synthetic dimension not available to ketones. In addition, improved procedures for the preparation and activation of imines/imine derivatives have increased the scope of the imine addition reaction.
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