Abstract
Chiral non-racemic 4-substituted 3,5-diacyl-1,4-dihydropyridines 8 are prepared by the regio- and diastereoselective addition of organocopper reagents to chiral pyridinium salt 2, followed by acylation with trichloroacetic anhydride and subsequent haloform reaction. Additionally, (−)- N a -methylervitsine is synthesized by reaction of the enolate derived from 2-acetylindole 9 with pyridinium salt 2, followed by electrophile (Me 2N +CH 2I −)-induced cyclization and subsequent elaboration of the 16-methylene and (20 E)-ethylidene substituents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
