Abstract
Eleven papillomas and 25 carcinomas were induced in rat tongues by oral administration of 0.001% 4-nitroquinoline 1-oxide (4NQO) in drinking water, and the biological characteristics and proliferative activity of the tumors were investigated by both DNA cytofluorometry and the argyrophilic nucleolar organizer region (AgNOR) staining method. The histopathological characteristics, the mean number of AgNORs per cell and DNA ploidy patterns were compared. The mean AgNOR number was lowest in normal epithelium (1.65 +/- 0.10), and highest in squamous cell carcinomas (2.97 +/- 0.70) and intermediate in papillomas (1.87 +/- 0.28). The differences were statistically significant. All normal epithelium and all papillomas showed a diploid pattern. Eighteen (72%) of 25 squamous cell carcinomas showed a diploid pattern, while 7 (28%) showed a diploid plus tetraploid pattern. There was a significant difference in the mean AgNOR number between the two ploidy groups of squamous cell carcinomas. These results suggest that the mean AgNOR number may reflect the histological grade in the process of carcinogenesis and polyploidization of carcinomas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
