Abstract
THE PRIMARY SITE of the host response in the case of skin homografts has been identified as the regional lymph nodes draining the graft. This has been demonstrated by a variety of techniques: passive transfer of immunity, 1 gross weight, 2 and histologic response. 2,3 Similar experiments have indicated that the spleen is also a site for this response. 1,3,4 Although the techniques employed in these experiments have provided valuable qualitative information about the host response, none, alone or in combination with each other, provides quantitative data about the host response. All of these techniques measure the amount of response in a tissue at a given time, and yet fail to measure the rate of response of the tissue. In the present experiments the rate of nucleic acid synthesis has been utilized as a measure of the rate of tissue response while the whole organ weight has been employed
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