Nucleic acid based intelligent systems and their biomedical applications

Abstract

Artificial intelligent molecular systems are playing a significant role in the field of biomedical applications. These logical systems could be used as processors to precisely control nanodevices in vitro , monitor biochemical reactions in situ and intelligently regulate gene expression in vivo . Nucleic acids are promising materials for construction of artificial intelligent molecular systems due to their nanometer-size, easy chemical synthesis, predictable base-pairing behavior and significant regulation ability on biomolecules. A number of nucleic acid-based intelligent systems have been constructed in last couple decades, including Boolean logical gates, molecular circuit or artificial neural network. They have been utilized to handle various challenges in the biomedical applications. This review will focus on the recent progress of nucleic acid-based intelligent systems and their biomedical applications.