Abstract
The resolution of racemic 1-(3-methoxyphenyl)ethylamine with ( S)-mandelic acid by diastereomeric salt formation can be made more economical by application of the Pope-Peachey method. This resolution was further improved upon by the addition of small amounts of a nucleation inhibitor, which prevents the formation of crystals of the more soluble diastereomer. The mandelic acid left in the solution is then used for further crystal growth of the less soluble diastereomer, furnishing high yields and diastereomeric excesses. Slow cooling and grinding of the crystals formed lead to increased secondary nucleation and thus to more consumption of the less soluble diastereomer and even better results.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
