Abstract
SEVERAL investigators1–4 have demonstrated RNA synthesis in normal and leukaemic lymphocytes by extraction of RNA from intact cells. To gather more information about RNA synthesis in human leukaemic leukocytes, experiments were designed to characterize nuclear RNA sedimentation patterns. Particular emphasis was placed on the comparison of nuclear RNA synthesis in cells derived from patients with chronic granulocytic leukaemia to those from patients with chronic lymphocytic leukaemia. These leukaemic cell types were chosen for investigation as examples of readily accessible human neoplastic cells of relatively low grade malignancy which appear to originate from two distinct haematopoietic cell lines.
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