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Abstract
Nuclear receptor modulation by kinesin.
Highlights
Estrogen related receptor alpha (ERR1) is an orphan nuclear receptor (NR) that plays a key role in adaptive energy and lipid metabolism, mitochondrial biogenesis, osteogenesis, and in regulation of blood pressure (Huss, JM, et al (2015)
KIF17 contains a nuclear localization signal, and both endogenous and overexpressed protein localizes to the cytoplasm and the nucleus
Depletion of KIF17 or expression of a KIF17 fragment lacking the NR box results in increased ERR1 activity in reporter assays. The effects of these latter treatments on specific ERR1 targets is not yet known, the nuclear localization of expressed KIF17 peptides suggests they modulate transcription by competing with other ERR1 cofactors for ERR1 binding in the nucleus
Summary
Estrogen related receptor alpha (ERR1) is an orphan nuclear receptor (NR) that plays a key role in adaptive energy and lipid metabolism, mitochondrial biogenesis, osteogenesis, and in regulation of blood pressure (Huss, JM, et al (2015). Editorial et al for KIF17 and ERR1 in breast cancer cells [1]. KIF17 contains a nuclear localization signal, and both endogenous and overexpressed protein localizes to the cytoplasm and the nucleus.
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