Abstract
Nuclear methylation of 2:4-dihydroxy-chalkones (III) give rise to 3-C-methyl derivatives just as in the case of resacetophenone. C-Methylchalkone-derivatives (IV) with substituents in the side phenyl nucleus have also been prepared by this method. For comparison, they have been synthesised using 3-methyl-peonol and appropriate derivatives of benzaldehyde. C-Methyl-iso-liquiritigenin-dimethyl-ether (IVb) was cyclised to the corresponding 8-methyl-flavanone (VI).
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