Abstract
Nuclear medicine imaging can provide important complementary information in the management of pediatric patients with neurological diseases. Pre-surgical localization of the epileptogenic focus in medically refractory epilepsy patients is the most common indication for nuclear medicine imaging in pediatric neurology. In patients with temporal lobe epilepsy, nuclear medicine imaging is particularly useful when magnetic resonance imaging findings are normal or its findings are discordant with electroencephalogram findings. In pediatric patients with brain tumors, nuclear medicine imaging can be clinically helpful in the diagnosis, directing biopsy, planning therapy, differentiating tumor recurrence from post-treatment sequelae, and assessment of response to therapy. Among other neurological diseases in which nuclear medicine has proved to be useful are patients with head trauma, inflammatory-infectious diseases and hypoxic-ischemic encephalopathy.
Highlights
Nuclear medicine offers noninvasive imaging methods, namely single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to study functional changes associated with neurological disorders [1]
Subtraction ictal SPECT co-registered to magnetic resonance imaging (MRI) called SISCOM is the most frequently used subtraction analysis technique that is considered as the gold standard for quantitative assessment in ictal/ interictal analysis of epilepsy patients
Standardized uptake value (SUV) was not shown to be useful in grading childhood brain tumors [52], and currently there is no consensus on the optimal quantitative method for brain tumor evaluation with F-18 FDG PET
Summary
Nuclear medicine offers noninvasive imaging methods, namely single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to study functional changes associated with neurological disorders [1]. The most common indication for nuclear medicine imaging in the pediatric population is epilepsy. That is why; nuclear medicine imaging in epilepsy is covered in more detail in this review article, while other indications are briefly mentioned. A general description of nuclear medicine imaging methods will be provided
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
