Abstract
Abstract Eukaryotic interphase chromosomes are thought to be organized in topologically independent loop domains. Such loops can be visualized emanating from permeabilized nuclei after extraction of histone proteins (Vogelstein et al. 1980; Jackson et al. 1984; Gerdes et al. 1994). At their bases the loops are fastened to the residual nuclear structure, which is known as nuclear matrix or nuclear scaffold. It is believed that the loop organization of chromatin is important not only for the compaction and spatial organization of the chromatin, but also for the regulation of gene expression. Each loop domain may represent an independent unit of chromatin structure and gene activity.
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