Abstract
Experimental Allergic Encephalomyelitis (E.A.E.) is induced in susceptible animals by immunodominant determinants of Myelin Basic Protein (MBP) [1]. Analogues of these desease- associated peptides have been identified which alter disease progression upon coimmunization. Based on the peptide sequence MBP72-85 of guinea pig, which has been found to be recognised by encephalitogenic T cell, two linear peptide analogues have been synthesized and their biological activity was assessed in the E.A.E. system. The linear analogue Gln1-Lys2-Ser3-Gln4-Arg -Ser6-Gln7-Asp8-Glu9-Asn10-Prou-Val12 (1) induces E.A.E. while substitution of Asp at position 8 with Ala results in an analogue (2) which suppresses the induction of E.A.E. [2].
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