Abstract
Systematic nuclear magnetic resonance investigation on 12 adamantane amides with potential biological activity is reported. The assignment of proton and carbon-13 chemical shifts shows similar trends in their spectral behavior, along with some structure-specific changes in the cases of aromatic substituents. The observations provide a good basis for future investigations, either as a tool for the database-assisted assignment of novel compounds or as a starting point for configuration and conformation analysis.
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