Abstract
A new nuclear <i>in vitro</i> continuous dissolution-rate measuring method has been developed and evaluated for use in determining the dissolution release rates of labeled materials from solid dosage forms. The results obtained were compared with dissolution rates of similar dosage forms using the U.S.P. disintegration apparatus and the rotating-bottle method. In all three cases the concentration of material released was directly proportional to the square root of time, although the release rates were different for each method. The nuclear method was found to be more precise than either the U.S.P. or rotating-bottle method.
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