Abstract
Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin.
Highlights
Misfolded proteins are detected shortly after their synthesis or after denaturation events, and are targeted to refolding
Prefoldin is not present in Eubacteria, but it is present in Archaea [6], suggesting that its ubiquitous presence in the eukaryotic kingdom is archaeal in origin [7]
Consistent with a role played by prefoldin in actin and tubulin folding, the deletion of prefoldin-encoding genes in Saccharomyces cerevisiae results in impaired cytoskeleton functions [2]
Summary
Present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. Both canonical and prefoldin-like subunits of this heterohexameric complex have been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has been detected in the nucleus and physically associated with a gene regulator. We summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin
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