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Abstract
Forkhead box O3a (FOXO3a) is a transcriptional regulator characterized by a conserved “forkhead box” DNA-binding domain. It is thought to be a tumor suppressor, with oncogenic PI3K/AKT signaling suppressing FOXO3a activity through phosphorylation, nuclear exclusion and eventual proteasomal degradation. In contrast to its tumor suppressor role, high FOXO3a expression has recently been associated with a worse prognosis in acute myeloid …
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