Abstract
Nuclear factor erythroid 2-related factor 2 (Nrf2) mitigates cell damage due to stress, environmental xenobiotics,and toxic chemicals. Nrf2 is present in the cytoplasm bound to its cysteine-rich Kelch domain-containingpartner, Kelch-like ECH-associated protein 1 (Keap1), where is ubiquitinated and degraded. In addition toinducers that disrupt the Keap1-Nrf2 complex, defective autophagy has recently been shown to upregulateendogenous p62, which interacts with Keap1 triggering transcriptional activation of Nrf2 in several cancers. Thisregulation by Nrf2-dependent transactivation of cytoprotective genes needs to be validated by clinical trials inview of its persistent activation in a p62-dependent manner when there is deregulation of autophagy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
