Nuclear factor erythroid 2-related factor 2 a master regulator of retinal vascular regeneration

Abstract

In this issue of PNAS, Wei and colleagues demonstrate that the Nuclear factor erythroid 2-related factor 2 (Nrf2), a well-known cell-intrinsic cytoprotective factor and critical regulator of the anti-oxidant response plays an important function in reparative angiogenesis by suppressing the antiangiogenic effects of Semaphorin 6A (Sema6A), a membrane-associated guidance molecule expressed by neurons during retinal ischemia (1).