Nuclear acidic protein changes in adenovirus-infected human embryo kidney cultures

Abstract

Adenovirus infection of human embryonic kidney cultures alters the metabolism of the nuclear nonhistone acidic proteins. Analysis by sodium dodecyl sulfate/polyacrylamide gel electrophoresis shows that infection inhibits the labeling with radioactive amino acids of some nuclear acidic proteins, while the rate of synthesis of other acidic proteins seems to be specifically stimulated. Because not all of the polypeptides having an enhanced rate of synthesis show the same electrophoretic mobilities as the acidic adenoviral structural polypeptides, there appears to be an induction of synthesis of acidic proteins which are nonvirus components.