NSAID naproxen in mesoporous matrix MCM-41: drug uptake and release properties

Abstract

Hexagonally ordered mesoporous silica material MCM-41 (SBET = 1090 m2/g, pore size = 31.2 A) was synthesized and modified by 3-aminopropyl ligands. The differences in an uptake and subsequent release of anti-inflammatory drug naproxen from unmodified and amino modified MCM-41 samples were studied. The prepared materials were characterized by high resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM), nitrogen adsorption/desorption, Fourier-Transform Infrared Spectroscopy (FT-IR), Small-angle X-ray scattering (SAXS), thermoanalytical methods (TG/DTA) and elemental analysis. The amount of the drug released was monitored with thin layer chromatography (TLC) with densitometric detection in defined time intervals. The amounts of the released naproxen from mesoporous silica MCM-41/napro and amine-modified silica sample A-MCM-41/napro were 95 and 90% of naproxen after 72 h. In this study we compare the differences of release profiles from mesoporous silica MCM-41 and mesoporous silica SBA-15.