Abstract
After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs’ biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs’ properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
Highlights
In the era of emerging drug resistance, mainly by bacteria, designing potent and successful novel therapeutic agents has become a major concern in the area of bioinorganic chemistry [1,2]
This review summarizes the biological activities of some Cu(II), Co(II), Mn(II), Ni(II) and Zn(II) metal coordination compounds with some NSAIDs, which are organized into different groups
Metal complexes containing NSAIDs are a group of compounds that have attracted much interest among the scientific community
Summary
In the era of emerging drug resistance, mainly by bacteria, designing potent and successful novel therapeutic agents has become a major concern in the area of bioinorganic chemistry [1,2]. Manganese is an essential element, and when as Mn(II), d5, it is associated with various physiological processes, such as development, reproduction and immune functions, energy metabolism and antioxidant defense [22] It is involved in the synthesis and activation of several enzymes (e.g., transferases, hydrolases and isomerases) by acting as a cofactor [17,23]. Ni(II) ions are mainly found associated with nucleic acids in humans, since they coordinate with DNA’s nitrogen-containing bases [34] It is involved in proteins structurally and functionality [30]. Even though Zn(II) complexes do not possess ligand field energy stabilization, they show wide coordination flexibility, especially with O donor atoms of amino acids or proteins [17] These characteristics (coordination numbers and structural variety) are critical in what concerns their catalytic roles in metalloenzymes, providing different interaction possibilities with substrates [36]. It is involved in several steps of cellular metabolism and is involved in respiration, immune functions, DNA synthesis and cell division [32,37,38]
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