Abstract
Ferroptosis is a novel form of cell death characterized by an imbalance of iron homeostasis and lipid peroxidation. It has been found to play a key role in guiding the fate of cells, and is closely related to the occurrence and development of a variety of diseases. One of the most important characteristics of ferroptosis is that it is unique not only in terms of morphology and biochemistry but also has a complex and diverse regulatory pathway network. NRF/CNC proteins, which act as important transcriptional activators, have recently been found to have a pivotal regulatory effect on ferroptosis through inhibition. Therefore, further research on the regulatory pathway of ferroptosis through NRF proteins could help to understand the development of various diseases and contemplate new ideas for corresponding treatments. This paper aims to summarize the regulatory roles played by NRF proteins, mainly NRF1 and NRF2, in the onset and development of ferroptosis and to describe the regulatory relationships and research prospects of ferroptosis in diseases
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