Abstract
BackgroundThe aim of the present study was to evaluate the association of NRAMP1 -3′UTR, 274-CT,VDR- Fok1 VDR-Taq1 Polymorphisms with the risk of pulmonary tuberculosis.MethodA case –control study was conducted on Andhra Pradesh Population of India. Analysis of gene polymorphisms of NRAMP1 gene (3′UTR, 274CT) and VDR gene (Fok1 and Taq1) was done by using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Tuberculosis (TB) patients and healthy controls. The obtained results were observed using 2% Agarose Gel electrophoresis and analysed statistically using Chi-square test and Odds Ratio.ResultsStatistical significance was observed between the patients and the controls in the NRAMP1-3′UTR (P = 0.005; OR = 2.997; 95% CI = 1.019–8.813) and VDR-Taq1 (P < 0.001; OR = 0.140;95% C.I = 0.050–0.386) polymorphisms in Andhra Pradesh population. No statistical significance was observed between patients and controls of the same population in NRAMP1-274CT and VDR-Fok1 polymorphisms (p > 0.05).Conclusion3′UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India.
Highlights
The aim of the present study was to evaluate the association of Natural –resistance-associated macrophage protein 1 (NRAMP1) -3′UTR, 274-CT,Vitamin D receptor (VDR)- Fok1 VDR-Taq1 Polymorphisms with the risk of pulmonary tuberculosis
Statistical significance was observed between the patients and the controls in the NRAMP1-3′UTR (P = 0.005; Odds Ratio (OR) = 2.997; 95% confidence interval (CI) = 1.019–8.813) and VDR-Taq1 (P < 0.001; OR = 0.140;95% C.I = 0.050–0.386) polymorphisms in Andhra Pradesh population
3′UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India
Summary
The aim of the present study was to evaluate the association of NRAMP1 -3′UTR, 274-CT,VDR- Fok VDR-Taq Polymorphisms with the risk of pulmonary tuberculosis. Tuberculosis (TB) is a chronic bacterial infection caused by Mycobacterium tuberculosis (M.tb). It is transmitted from one individual to other by direct inhalation of droplet nuclei formed through coughing, sneezing etc. It can affect any part of the human body mainly the lungs causing Pulmonary Tuberculosis (PTB). It is the major cause of mortality and morbidity globally. The infection is multifactorial, both environmental and host genetic factors acting as the influencing agents [1]. India accounts for more than one fourth of the world’s TB cases and deaths [2]
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