Nöral Terapi Perspektifinden Lokal Anesteziklerin Virüsler Üzerindeki Etkileri

Abstract

Viral infections have become one of the major health problems of today's world. Especially the current coronavirus disease2019 outbreak, causing systemic complications and mortality, has led to a serious pandemic worldwide. The disease has a wide clinical spectrum ranging from asymptomatic mild form to multiorgan failure and death. Although there is no treatment for coronavirus infection, some medications are used to suppress the inflammation. For this reason, the anti-inflammatory treatments have drawn attention to itself. Local anesthetics which are anti-inflammatory drugs have been effective in several steps on inflammatory cascade. In our daily practice, one of the treatment methods with local anesthetics is neural therapy which is special injection techniques (local, segmental, ganglion and interference area injections) and are applied to certain parts of the body for diagnosis, treat inflammatory diseases, pain and dysfunctions. With the local anesthetic usage, the autonomic nervous system is regulated via inhibition of abnormal stimuli transmitted by this system and controlling information pathways between cells. At the same time, the antiviral and anti-inflammatory effects of local anesthetics have been shown in various studies. It is considered that local anesthetics have anti-inflammatory effects by regulation of synthesis and release of anti-inflammatory mediators and antiviral effects by releasing of free radicals from lysozyme and inhibiting of membrane ATP-ase. In this review, we aimed to discuss the effects of local anesthetics and neural therapy on viral infections in the light of the literature and evaluate their possible beneficial effects on coronavirus infection.