Abstract
Glyphosate is a highly effective, low-toxicity, broad-spectrum herbicide, which is extensively used in global agriculture to control weeds and vegetation. However, glyphosate has become a potential threat to human and ecosystem because of its excessive usage and its bio-concentration in soil and water. Herein, a novel turn-on fluorescent probe, N-n-butyl-4-(3-pyridin)ylmethylidenehydrazine-1,8-naphthalimide (NPA), is proposed. It efficiently detected Cu2+ within the limit of detection (LOD) of 0.21 μM and displayed a dramatic turn-off fluorescence response in CH3CN. NPA-Cu2+ complex was employed to selectively and sensitively monitor glyphosate concentrations in real samples accompanied by a fluorescence turn-on mode. A good linear relationship between NPA and Cu2+ of glyphosate was found in the range of 10–100 μM with an LOD of 1.87 μM. Glyphosate exhibited a stronger chelation with Cu2+ than NPA and the system released free NPA through competitive coordination. The proposed method demonstrates great potential in quantitatively detecting glyphosate in tap water, local water from Songhua River, soil, rice, millet, maize, soybean, mung bean, and milk with mild conditions, and is a simple procedure with obvious consequences and no need for large instruments or pretreatment.
Highlights
Glyphosate (N-(phosphonomethyl) glycine) is an efficient, low-toxicity, and nonselective herbicide against perennial weeds [1]
Glyphosate is a potential endocrine disruptor and exhibits adverse effects on cell cycle regulation [6,7]. It is classified as a potential carcinogen and genotoxic to humans by the International Agency for Research on Cancer (IARC) [8]
NPA was synthesized as an indicator of Cu2+ with turn-off fluorescence through coordination, and the limit of detection (LOD) for Cu2+ detection was found to be 0.21 μM
Summary
Glyphosate (N-(phosphonomethyl) glycine) is an efficient, low-toxicity, and nonselective herbicide against perennial weeds [1]. It is widely used in economic crops or trees such as orchards, rice, maize, soybeans, wheat, and tea fields [2,3,4]. Glyphosate is a potential endocrine disruptor and exhibits adverse effects on cell cycle regulation [6,7]. It is classified as a potential carcinogen and genotoxic to humans by the International Agency for Research on Cancer (IARC) [8]. Establishing a convenient and reliable method for the accurate and rapid detection of glyphosate is necessary and of great urgency
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