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Abstract
We investigated the role of NADPH oxidase(Nox)4 in colon cancer development.The expression of Nox4, unlike Nox1,was specifically induced in colon carcinoma and was quite similar to that of transforming growth factor-β(TGF-β)1. TGF-β1 treatment of colon cancer cells upregulated the Nox4 expression and ROS production through SMAD3.Knockdown of Nox4 suppressed TGF-β1-induced cell motility.Nox4 modulated the Rho activity through redox regulation of the low molecular weight protein tyrosine phosphatase(LMWPTP)-p190RhoGAP pathway upon TGF-β1 stimulation. These finding suggests that Nox4 contributes to TGF-β1-dependent motility of colon carcinoma through the LMW-PTP-p190RhoGAP-Rho signaling pathway.Shinshu Med J 63 : 281―293, 2015 (Received for publication March 23,2015;accepted in revised form June 16,2015)
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