Abstract
NOX4: A Guilty Party in Stroke Damage
Highlights
Ischemic stroke is a dangerous medical condition that occurs when blood supply to brain tissues is lost. This usually happens as a result of substantial blood pressure drops, or when blood vessels are blocked by clots
If tissue death could be prevented until the blood supply is restored, stroke prognosis could be improved
The mechanisms underlying this damage are still poorly understood, and so far only one effective treatment exists. This treatment, a blood-thinning medication intended to disintegrate blood clots, can’t be used in most patients without risk of serious complications. This lack of effective treatments for stroke is becoming ever more urgent as the generation born in the baby boom after WWII are reaching an age where stroke is of particular concern
Summary
Ischemic stroke is a dangerous medical condition that occurs when blood supply to brain tissues is lost. If tissue death could be prevented until the blood supply is restored, stroke prognosis could be improved. Headed by Christoph Kleinschnitz (Germany) and Harald Schmidt (The Netherlands), the group set its sights on the potential for oxidative stress to cause tissue damage after stroke.
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