Abstract
The abilities of endothelial cells (EC) to proliferate, to be quiescent and to undergo apoptosis during remodelling are important determinants relating to angiogenesis, wound healing and many cardiovascular diseases. EC express constitutively an NADPH oxidase, which is a major source of superoxide production. The catalytic subunit of NADPH oxidase has several isoforms (Nox1–5). However, their individual roles in endothelial function remain unknown. In this study, we investigated the role of Nox2 in nutrient deprivation-induced cell cycle arrest and apoptosis.
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