Abstract
The Schiff base ligand, 4-nitrobenzaldehyde-glycylglycine (4-NBA-GG) and its Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized and characterized by elemental analysis, mass, NMR, IR, electronic spectra, magnetic moment, molar conductance, ESR, CV, TGA, and powder XRD. All the complexes were found to be soluble in water. According to the spectral analysis, the 4-NBA-GG acts as a tridentate monobasic donor coordinating through the azomethine nitrogen, carboxylato oxygen and deprotonated peptide nitrogen atoms. The geometrical structures of these complexes are found to be octahedral. Antimicrobial studies of the synthesized compounds were evaluated and reported. The DNA cleavage activities were assayed against E. coli DNA, besides, anticancer activities was also studied towards human Colon Cancer Cells (HCT116) and cervical cancer cell line (HeLa). The obtained results showed that the complexes, especially Cu(II) and Zn(II) complexes strongly interact with E. coli DNA and active against both cancer cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
