Abstract
Paecilomycine A ( 1 ), B ( 2 ), and C ( 3 ) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes ( Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1– 3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.
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