Novel Treatments and Technologies Applied to the Cure of Neuroblastoma.

Irene Paraboschi,Gabriela Kramer-Marek,John Anderson,Laura Privitera,Stefano Giuliani

doi:10.3390/children8060482

Abstract

Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment.

Highlights

Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population [1]
This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment
PD-1 blockade augments anti-NB immune response induced by anti-GD2 antibody ch14.18/CHO

Summary

Introduction

Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population [1]. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment.

Objectives

Results

Conclusion