Abstract
A series of thienopyrimidine oxadiazolederivatives (5a-l) were synthesized by cyclic condensation of substituted aroylhydrazides with triazole of carboxylic acid (4a-c). The synthesized compounds were characterized on the basis of their spectral (IR, 1H and 13C NMR) data and screened for antimicrobial activity where compounds 5b and 5d showed significant activity.
Highlights
The firm appearances of microbial infections followed by the spreading out of numerous resistant bacterial and fungal strains against clinically used antimicrobial have insist on medicinal communities to look for new incorporations into the current methods used in medicine
Taking the above points in consideration, we have studied the antimicrobial action of the resultant thienopyrimidine 1,2,4-triazole and 1,3,4-oxadiazole derivatives against wide range of different microorganisms
The reaction sequences employed for synthesis of title compounds are shown in (Scheme 1)
Summary
The firm appearances of microbial infections followed by the spreading out of numerous resistant bacterial and fungal strains against clinically used antimicrobial have insist on medicinal communities to look for new incorporations into the current methods used in medicine. Yield: 69% (pale brown color solid); m.p. 187-189°C; IR (KBr) (νmax/cm-1): 2880, 1639, 1585, 1155; 1H NMR (400 MHz; DMSO-d6): δH 1.27 (s, 3H, CH3), 1.96 (s, 3H, CH3), 6.85 (d, JHH = 12.0 Hz, 2H, Ar-H), 7.16 (d, JHH = 8.0 Hz, 2H, Ar-H), 7.29 (d, JHH = 8.0 Hz, 2H, Ar-H), 7.82 (d, JHH = 8.0 Hz, 2H, Ar-H), 8.69 (s, 1H, CH-pyrimidine); 13C NMR (100 MHz; DMSO-d6): δC 14.32, 21.75, 118.19, 120.08, 124.45, 125.09, 126.96, 129.70, 131.43, 133.00, 137.31, 139.16, 141.45, 145.21, 148.39, 153.27, 157.11, 163.08, 166.74; LC-MS (70 eV): m/z = 459 (M+H)+. The fungal zone of inhibition values are given in (Table 2)
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