Abstract

Advanced glycation end-products (AGEs) play a pivotal pathogenic role in ageing and diabetes. With IRB approval and informed consents, we showed adverse effects of AGE accumulation on ART outcomes in study I and in study II we improved ART outcomes in aged patients with repeated ART failures by reducing AGEs with Hishi-extract, anti-glycation functional food, which suppresses AGE production and also break down AGEs.

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