Abstract
Lung cancer is amongst the deadliest form of cancer that categorized in two main groups as small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), which arises more often and typically grows at a slower rate than SCLC. Treatment limitations due to the side effects and resistance to the current therapeutics’ mandates development of alternative agents. In this study, novel tetracyclic spermine derivatives of cyclotriphosphazene (6–8) were designed and synthesized and their effects were investigated in NSCLC cell lines and non-tumoral counterparts. First, the reactions of dispiroansa (tetracyclic) spermine substituted cyclotriphosphazene derivative (2) with pyrrolidine (3), piperidine (4) and cyclopropylmethanamine (5) were performed, respectively and synthesised products (6–8) were characterized by FT-IR, MALDI-TOF MS, 1H, 31P NMR spectroscopies and single crystal X-ray (for compound 7) crystallography. Then, the anti-carcinogenic properties of compounds have been determined by viability and cell death assays. Our results indicated that compared to others, compound 8 that is formed by the substitution reaction of compounds 2 and 5 has a potential anti-cancerogenic effect on lung cancer cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
