Abstract
In this study, we proposed a novel pulse wave velocity (PWV) technique to determine cerebrovascular stiffness using a 3-tesla magnetic resonance imaging (MRI) to overcome the various shortcomings of existing PWV techniques for cerebral-artery PWV, such as long scan times and complicated procedures. The technique was developed by combining a simultaneous multi-slice (SMS) excitation pulse sequence with keyhole acquisition and reconstruction (SMS-K). The SMS-K technique for cerebral-artery PWV was evaluated using phantom and human experiments. In the results, common and internal carotid arteries (CCA and ICA) were acquired simultaneously in an image with a high temporal resolution-of 48 ms for one measurement. Vascular signals at 500 time points acquired within 30 s could generate pulse waveforms of CCA and ICA with 26 heartbeats, allowing for the detection of PWV changes over time. The results demonstrated that the SMS-K technique could provide more PWV information with a simple procedure within a short period of time. The procedural convenience and advantages of PWV measurements will make it more appropriate for clinical applications.
Highlights
A stroke is a neurological deficit caused by vascular injury in the central nervous system and the second leading cause of mortality worldwide
We developed a new technique for Pulse wave velocity (PWV) using a simultaneous multi-slice technique (SMS), which takes two target images simultaneously, without the need to synchronize blood transit times, and a keyhole technique that collects dynamic blood flow signals while significantly reducing scan times
We found that CCA and internal carotid artery (ICA) vessels were positioned at the same location in both the SMS and keyhole techniques (SMS-K)
Summary
A stroke is a neurological deficit caused by vascular injury in the central nervous system and the second leading cause of mortality worldwide. It is responsible for a variety of diseases, including permanently acquired disability, late-onset dementia, and epilepsy in elderly individuals [1]. Recent studies have shown that methods for risk factor detection and stroke prevention are of great importance [2,3,4,5,6] Cardiovascular diseases such as hypertension, heart failure, and atrial fibrillation, which are known as the major risk factors for stroke [7], are affected by vascular stiffness. The loss of arterial elasticity can reduce the ability to store and supply blood to distal tissues and is closely related to cardiovascular diseases, including hypertension [10], coronary artery disease [11] and heart failure [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
