Novel Technique for Epinephrine Removal in New Generation Autoinjectors

Abstract

Anaphylaxis is a severe, life-threatening, multisystem hypersensitivity reaction that can rapidly progress to hypotension and airway compromise. Successful management of anaphylaxis has been documented with the use of prescription intramuscular epinephrine pens that require only minimal training for safe use. The prior generations of these commercially available autoinjectors were produced for single use; however, safe removal of multiple doses has been demonstrated for use in dire situations. We aim to show a novel technique for removal and administration of additional doses of epinephrine from the new generation autoinjector, the Auvi-Q. There was a voluntary manufacturer recall of this product as of October 30, 2015, because of concerns about inaccurate dosing. However, an uncertain number of devices remain in public hands.