Abstract
An efficient, novel, task-specific ionic liquid, [2-hydroxymethylpyridinium butanesulfonic acid]HSO4 has been designed for the rapid synthesis of spiro-1,2,4-triazolidine-3-thiones from isatins and thiosemicarbazides in water as an universal solvent at room temperature. The hydroxymethyl functionality tethered to pyridinium nucleus facilitates the reaction in water. This is the first method proceeded at room temperature for synthesis of spiro-1,2,4-triazolidine-3-thiones. The novelty of the method is synthesis of novel task-specific ionic liquid, energy efficiency, atom economy, wide substrate scope, shorter reaction time, high yield of products, and use of water along with ionic liquid are greener aspects of present method.
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