Abstract
N-acetylcysteine (NAC) is mainly administrated as a mucolytic medication, antioxidant supplement, antidote in paracetamol overdose, and a drug for the prevention of diabetic kidney disease. Its effect has been investigated for the treatment of several diseases such as COVID-19. In this work, an effective method for high-yield synthesis of N-acetylcysteine is proposed. This drug can be synthesized in a single-batch step instead of using a multi-stage process. The proposed method has shown the potential to be considered as an alternative method for producing NAC. The purification process was carried out using suitable solvents to reach a high level of purity. The characterization of the synthesized drug was undertaken through Elemental analysis, Proton Nuclear Magnetic Resonance (1H NMR), High Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectroscopy (FT-IR), and melting point analyses.
Highlights
Synthesis of N-Acetylcysteine N-acetylcysteine is an antioxidant and is used as an antidote to paracetamol overdose, it has many other applications supported by clinical evidence
The purification process was carried out using suitable solvents to reach a high level of purity
High Performance Liquid Chromatography (HPLC) analysis was used for further purification and measuring the purity of synthesized N-acetylcysteine
Summary
N-acetylcysteine is an antioxidant and is used as an antidote to paracetamol (acetaminophen) overdose, it has many other applications supported by clinical evidence. N-acetylcysteine can be administrated as a mucolytic or lung anti-inflammatory drug, and as an antioxidant, and the precursor of glutathione to replenish the level of glutathione in the body. Because of this feature, N-acetylcysteine may be considered as a COVID-19 preventive-therapeutic medicine, as it has previously demonstrated its remedial effects on influenza and influenza-like sicknesses [8]. The advantage of using the corresponding N-acylbenzotriazole as an effective acylation agent is taken into account to form a peptide bond with L-cysteine amino acid [14,15] It can be considered as an alternative method to be replaced with the complicated multi-stage process, which is used for making this drug
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