Abstract
A new route for the synthesis of 2-arylcyclohexanones starting from cyclohexanones was established. This synthetic route involves electrochemical oxidation as the key step and consists of the following four reaction steps: conversion of cyclohexanone ( 1) to the corresponding enol acetate ( 2), anodic oxidation in methanol providing 2-methoxycyclohexanone ( 3), Grignard reaction for introduction of an aryl group affording 1-aryl-2-methoxycyclohexanols ( 6) and acid-catalyzed treatment forming the 2-arylcyclohexanones ( 7). Thus, cyclohexanones bearing a variety of aryl groups at the α-position were prepared in good yields according to this newly developed method. This transformation starting from 1 to 7 may be characterized as a unique arylated 1,2-transposition of the carbonyl group.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
