Abstract
The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.
Highlights
Zeolites are inorganic, crystalline, microporous, and aluminotectosilicates with an open framework of SiO4 and AlO4 tetrahedra, connected via oxygen atoms at their corner points
The presence of natural resources necessary for their production such as rocks, volcanic tuffs, pumice, and diatomite is a matter of economic interest
In our previous study [64], we found that Ag-substituted Zeolites-A has an effective antitumor effects
Summary
Crystalline, microporous, and aluminotectosilicates with an open framework (ring structure) of SiO4 and AlO4 tetrahedra, connected via oxygen atoms at their corner points. The three-dimensional structure of Zeolites generates uniformly sized interconnected micropores and channels which form sharply defined, two- or three-dimensional channel systems of molecular dimensions in 0.3–1.4 nm range where cations, large molecules, and even cationic groups (as water, ammonia, carbonate and nitrate anions, etc.) are present [1]. Water molecules are removable (i.e., sorbed/adsorbed) where alkali cations seem to be exchanged. These channels are identified by its direction relative to the crystallographic axes. More than 46 Zeolite minerals are naturally occurring and more than 150 synthetic structures are present in the literature. Synthetic Zeolites are used commercially more than the natural ones due to their purity, degree of crystallinity, and pore-size uniformity [3]. The presence of natural resources necessary for their production such as rocks, volcanic tuffs, pumice, and diatomite is a matter of economic interest
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