Abstract
The family Orthomyxoviridae consists of Influenza A virus which is negative sense single stranded virus. The genome of the virus is segmented and possesses a peculiar trait of genetic reassortment. The influenza virus on its envelop consists of the antigenic glycoprotein like haemagglutinin (HA) and neuraminidase (NA). The changes in those glycoprotein components due to antigenic shift and antigenic drift leads to the development of new strain of Influenza A viruses. Now the novel swine influenza A/H1N1 strain has been detected from different parts of the world which is causing pandemic. World Health Organization has declared the pandemic phase six and more than 60 countries have reported the cases of novel influenza A/H1N1 strain including Nepal. As the disease is spreading world wide, it is a major public health concern for all the countries. And especially the developing countries like Nepal should immediately respond to the situation and should be well prepared to combat the disease before the disease spreads to enough population.
Highlights
Orthomyxoviridae family consists of four generaInfluenza A, Influenza B, Influenza C and Thogotovirus.[1,2] It consists of segmented, negative sense RNA and is enveloped
Influenza A virus can be further divided into various subtypes on the basis of antigenic characters possessed due to presence of surface glycoproteinshaemagglutinin (HA) and neuraminidase (NA).[3]
The influenza is transmitted to the other species from this natural host and the swine plays the vital role in the epidemiology of influenza.[6]
Summary
Orthomyxoviridae family consists of four generaInfluenza A, Influenza B, Influenza C and Thogotovirus.[1,2] It consists of segmented, negative sense RNA and is enveloped. The virus can undergo genetic reassortment and relatively rapid and unpredictable antigenic changes.[7]
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