Abstract
Novel Strategy to Prevent Otitis Media Caused by Colonizing Streptococcus pneumoniae
Highlights
Fischetti are with the Laboratory of Bacterial Pathogenesis, Rockefeller University, New York, New York, United States of America
The Cpl-1 lysin was 100% effective in preventing acute otitis media (AOM), as no animal treated with lysin developed a secondary bacterial infection following influenza infection, while eight of ten (80%) mice that were mock-treated developed AOM (Figure 2)
In the one mouse in which colonization persisted despite lysin treatment, the amount of bacteria present decreased dramatically
Summary
Fischetti are with the Laboratory of Bacterial Pathogenesis, Rockefeller University, New York, New York, United States of America. The Cpl-1 lysin was 100% effective in preventing AOM, as no animal treated with lysin developed a secondary bacterial infection following influenza infection, while eight of ten (80%) mice that were mock-treated developed AOM (Figure 2). In the one mouse in which colonization persisted despite lysin treatment, the amount of bacteria present decreased dramatically
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