Abstract
Purpose: The paper reviews the obstacles that face CAR-T cells in solid tumors and the suggested novel strategies to overcome these obstacles in association with the efficacy as well as the safety profile of CAR-T cell therapy. Subjects and Methods: This is a systematic review exploring the novel strategies to improve CAR-T cells in solid tumors. Results: Several strategies have been developed, including: 1) targeting multiple antigens; 2) improving trafficking of CAR-T cells into tumor tissues; 3) Preventing the immunosuppression of TME on CAR-T cells by different approaches such as blocking the recruitment of MDSCs or TAM in TME, saving CAR-T cells viability from exhaustion by blocking negative signals, and enhancement of CAR-T cells persistence activity by blocking PD-1/PDL-1 pathway in TME, 4) designing novel CAR-T cells to prevent the exhaustion; and 5) inducing a self T cells response in the tumor-bearing host to prevent tumor escape and enhance CAR-T cells activity. Conclusions: Recent researches about CAR-T cells therapy carries new hope for targeting solid tumors.
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